Egalet has built a robust pipeline built around products developed using its Guardian™ Technology, and through business development. ARYMO ER is the first approved and marketed product to use Guardian Technology. The Company licensed and acquired OXAYDO and SPRIX Nasal Spray.

AD = abuse-deterrent; ER = extended release.
*Management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.
SPRIX is a registered trademark of Egalet Corporation.
ARYMO ER is a registered trademark of Egalet Corporation.