Egalet® Delivery Systems
We have created two distinct drug delivery systems, each with novel abuse-deterrent features and the ability to control the release profile of the active pharmaceutical ingredient, or API. We use an injection molding technology that is used in the manufacture of medical devices, including implants and diagnostics, to create our matrix and shell. Abusers often seek to accelerate the absorption of opioids into the bloodstream by crushing in order to swallow, snort, or smoke, or dissolving in order to inject, the drug. Tablets produced using our systems have physical and chemical barriers intended to deter these common methods of abuse.
Egalet® One-Component System
Our one-component system produces tablets that consist of a hard matrix that is difficult to crush, grind or dissolve and that also controls the release of the API. The matrix, which contains the API as well as inactive agents known as excipients, erodes over time in the gastrointestinal, or GI, tract, releasing the API.
One-Component Features
- Made to resist crushing in order to swallow, snort or smoke, and dissolving in order to inject.
- With its gelling effect, the one-component system was designed in particular to further deter abuse by injection
Egalet® Two-Component System
Our two-component system is used to produce tablets that consist of a matrix similar to the matrix that is a part of our one-component system, but that is surrounded by a water-impermeable, non-eroding, hard shell made of polylactic acid that creates a cylinder, with the API-containing matrix exposed at both ends. The shell serves to limit the portion of the matrix’s surface area that is exposed to the GI tract, which allows us to tailor the release rate of the API and makes it even more difficult to crush or grind the tablet, thereby enhancing its abuse-deterrent properties.
