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2004 IVIVC and Egalet® 2004 IVIVC and Egalet®
2001 Entrepreneur Of The Year® 2001 Entrepreneur Of The Year®
2001 USD 13.3 million financing 2001 USD 13.3 million financing
2001 Calcitonin absorbtion 2001 Calcitonin absorbtion
2001 Proof of concept 2001 Proof of concept
January 2004
 
IVIVC and Egalet®: An illustration of the problem for sophisticated oral drug delivery systems 
 
WW Lee, L Slot, D Bar-Shalom and CG Wilson.
 
This series of investigations has attempted to quantify the interaction of physicochemical and physiological factors and has yielded data which has helped in the optimization of the Egalet® system. The Egalet® device was shown to deliver and release the incorporated dose to the proximal colon5. The rate of release seen in vivo and in vitro are similar for the first 3-4 hours and thereafter the in vivo release slows down relative to the in vitro measurements. Although the focus of the studies was the Egalet® technology, the results are applicable to other oral drug CR delivery systems.
 
To read the complete article by Drug Delivery systems & sciences, please follow this link and observe the document size of 1200 KB.
 
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